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Pancreatic tumours as part of the MEN-1 syndrome

✍ Scribed by Göran Åkerström; Ola Hessman; Per Hellman; Britt Skogseid


Book ID
108074567
Publisher
Elsevier Science
Year
2005
Tongue
English
Weight
284 KB
Volume
19
Category
Article
ISSN
1521-6918

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The gene responsible for multiple endocrine neoplasia type I (MEN-l) syndrome has been mapped to chromosome l lq13. It appears to function as a tumoursuppressor gene analogous to that for retinoblastoma and allelic losses involving the wild-type of the MEN-1 allele have been found in parathyroid and