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Pancreatic stellate cells promote the hapto-migration of pancreatic cancer cells through collagen I mediated activation of alpha2beta1 integrin pathway

✍ Scribed by Lu, Jing; Zhou, Shaoxia; Siech, Marco; Habisch, Hansjoerg; Seufferlein, Thomas; Bachem, Max.


Book ID
122002130
Publisher
S. Karger AG
Year
2013
Tongue
English
Weight
55 KB
Volume
13
Category
Article
ISSN
1424-3903

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## Abstract The authors have previously demonstrated that Ξ±~2~Ξ²~1~ integrin‐mediated pancreatic cancer cell adhesion to Type I collagen is Mg^2+^‐dependent, inhibited by Ca^2+^, and that this integrin, purified from cell lysates using Type I‐collagen‐sepharose in Mg^2+^, can be eluted with Ca^2+^.

Aberrant expression and activation of in