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Pancreatic stellate cells activate chemokine receptor CCR9 signaling to promote pancreatic cancer cell invasion

✍ Scribed by Wendy Lee; Xiaoming Shen; Maithao N. Le; Marjun P. Duldulao; Jianming Lu; Julio Garcia-Aguilar; Joseph Kim

Book ID: 113680550
Publisher: Elsevier Science
Year: 2011
Tongue: English
Weight: 95 KB
Volume: 213
Category: Article
ISSN: 1072-7515
DOI: 10.1016/j.jamcollsurg.2011.06.018

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## Abstract Glutamate has been implicated in tumorigenesis through activation of alpha‐amino‐3‐hydroxy‐5‐methyl‐4‐isoxazolepropionic acid (AMPA) receptors (AMPAR). However, the function of a glutamate‐to‐AMPAR signal in pancreatic ductal adenocarcinoma (PDAC) has remained elusive. We now show that