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Pancreatic ductal adenocarcinoma and acinar cells: a matter of differentiation and development?

✍ Scribed by Rooman, I.; Real, F. X.

Book ID: 118151704
Publisher: BMJ Publishing Group
Year: 2011
Tongue: English
Weight: 358 KB
Volume: 61
Category: Article
ISSN: 0017-5749
DOI: 10.1136/gut.2010.235804

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## Abstract Pancreatic adenocarcinoma is a disease with high mortality for which chronic pancreatitis confers a markedly increased risk. We hypothesize that chromosome instability and genomic damage occur in pre‐neoplastic pancreatic ductal epithelium, and that this damage may be related to oxidati