✦ LIBER ✦

Pancreatic cancer stem cells and relevance to cancer treatments

✍ Scribed by Filip Bednar; Diane M. Simeone

Publisher: John Wiley and Sons
Year: 2009
Tongue: English
Weight: 97 KB
Volume: 107
Category: Article
ISSN: 0730-2312
DOI: 10.1002/jcb.22093

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Pancreatic cancer continues to be a malignancy with few therapeutic options. The majority of patients that present for an evaluation have locally advanced or metastatic disease that is incurable by surgical approaches. Chemotherapy and radiotherapy resistance of pancreatic adenocarcinomas limits the efficacy of these therapeutic approaches. Recent evidence supports the existence of human pancreatic cancer stem cells, which appear to drive tumor initiation and progression and are particularly resistant to cell death induced by radiation or chemotherapy. Understanding the mechanisms of pancreatic cancer stem cell self‐renewal and resistance to standard therapies may lead to new, more effective therapies to treat this dismal disease. J. Cell. Biochem. 107: 40–45, 2009. © 2009 Wiley‐Liss, Inc.

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