Pancreatic cancer, blood glucose and beverage consumption

✍ Scribed by Robert A. Hiatt; Arthur L. Klatsky; Mary Anne Armstrong

• Book ID: 102278044
• Publisher: John Wiley and Sons
• Year: 1988
• Tongue: French
• Weight: 416 KB
• Volume: 41
• Category: Article
• ISSN: 0020-7136
• DOI: 10.1002/ijc.2910410603

✦ Synopsis

We studied the incidence of pancreatic cancer in 122,894 METHODS men and women who had previously reported amount and frequency of coffee, tea, and alcohol consumption; reporting population at risk was done at a multi-phasic health check-up (MHC) taken while Members of the Kaiser Permanente Medical Care Program subjects were members of a large Prepaid health Plan. w e (KPMCP) in Northern California who had a MHC from 1978 also tested the hypothesis that a Pre-CliniCal effect of Pan-through 1984 were selected for study. During that period, creatic cancer on glucose homeostasis leads to mild hyperglytitularly coffee) reported in association with pancreatic cancer habits, and level and type of alcohol consumption. A blood in some case-control studies. However, in the 49 pancreatic glucose determination was included in a panel of tests percancer cases diagnosed during 6 years of follow-up, we found formed on blood drawn after a 4-hr fast. During the 6 years of no evidence of increased risk associated with coffee, tea, or follow-up, more than 449,000 person-years of observation alcoholic beverages. We also found no evidence to support the increased-thirst hypothesis when we examined the I 9 cases 40 8 years; 44.1% were men; 60.4% were white (including diagnosed within I 2 months of having MHC. We did confirm a significantly increased risk among cigarette smokers (relative risk, 2.5; 95% confidence interval, 1.3-4.7) which was progres-Cases and controls sive with increasing levels of cigarette use. In addition, risk of pancreatic cancer was greater for persons previously under