Pancopride, a potent and long-acting 5-HT3 receptor antagonist, is orally effective against anticancer drug-evoked emesis

The synthesis of the carbonyl-14C analog

The synthesis of the carbonyl-14C analog of zatosetron maleate, a potent, long-acting, orally effective 5-HT3 receptor antagonist

✍ Douglas D. O'Bannon; William J. Wheeler 📂 Article 📅 1991 🏛 John Wiley and Sons 🌐 French ⚖ 319 KB

## Abstract __Endo__‐5‐chloro‐2,3‐dihydro‐2,2‐dimethyl‐N‐(8‐methyl‐8 ‐azabicyclo‐[3.2.1.]‐oct‐3‐yl‐7‐benzofurancarboxamide‐[carbonyl‐^14^C] (Z)‐2‐butenedioate (zatosetron‐[^14^C] maleate, 1), has been prepared from 5‐chloro‐7‐bromo‐2,3‐dihydro‐2,2‐dimethylbenzofuran (5) in four radiochemical steps