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Panaxydol induces apoptosis through an increased intracellular calcium level, activation of JNK and p38 MAPK and NADPH oxidase-dependent generation of reactive oxygen species

โœ Scribed by Joo Young Kim; Su-Jin Yu; Hyun Ju Oh; Ji Young Lee; Yongjin Kim; Jeongwon Sohn


Publisher
Springer
Year
2010
Tongue
English
Weight
1007 KB
Volume
16
Category
Article
ISSN
1360-8185

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## Abstract Fenretinide, which mediates apoptosis in neuroblastoma cells, is being considered as a novel therapeutic for neuroblastoma. The cytotoxic mechanisms of fenretinide, however, have not been fully elucidated. Sustainedโ€activation of JNK and p38 MAPK signaling has been shown recently to hav