Pallidal deep brain stimulation improves quality of life in segmental and generalized dystonia: Results from a prospective, randomized sham-controlled trial
✍ Scribed by Joerg Mueller; Inger M. Skogseid; Reiner Benecke; Andreas Kupsch; Thomas Trottenberg; Werner Poewe; Gerd H. Schneider; Wilhelm Eisner; Alexander Wolters; J.U. Müller; Günther Deuschl; Marcus O. Pinsker; Geir K. Roeste; Juliane Vollmer-Haase; Angela Brentrup; Martin Krause; Volker Tronnier; Alfons Schnitzler; Jüergen Voges; Guido Nikkhah; Jan Vesper; Markus Naumann; Jens Volkmann
- Publisher
- John Wiley and Sons
- Year
- 2008
- Tongue
- English
- Weight
- 116 KB
- Volume
- 23
- Category
- Article
- ISSN
- 0885-3185
No coin nor oath required. For personal study only.
✦ Synopsis
Abstract
As part of the first randomized, sham‐timulation controlled trial on deep brain stimulation (DBS) in primary segmental or generalized dystonia, health‐related quality of life (HRQoL) was assessed by SF‐36. After the 3‐month sham‐controlled phase, significant HRQoL improvement occurred only in the active‐stimulation group. The open‐label extension phase resulted in a significant improvement in all SF‐36 domains following 6 months of neurostimulation. These results demonstrate a favorable impact of DBS on HRQoL in primary dystonia. © 2007 Movement Disorder Society