𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Palladium(II) pincer complexes of α-amino acids: towards the synthesis of catalytically active artificial peptides

✍ Scribed by Gabriela Guillena; Gema Rodrı́guez; Gerard van Koten

Book ID
104251074
Publisher
Elsevier Science
Year
2002
Tongue
French
Weight
72 KB
Volume
43
Category
Article
ISSN
0040-4039

No coin nor oath required. For personal study only.

✦ Synopsis

NCN palladium(II) complexes have been covalently attached to the N-and C-termini of L-valine and to the N-terminus of the dipeptide L-Phe-L-Val-OMe. Remarkably, the hydrolysis of the NCN-Pd(II) L-Val-OMe compound afforded the corresponding palladated, free amino acid without affecting the metal site. This deprotected amino acid could be coupled to any protein, enzyme or peptidic chain by simple peptide chemistry. These bioorganometallic systems were active as catalysts in the aldol reaction between methyl isocyanate and benzaldehyde.

📜 SIMILAR VOLUMES

Catalytic Performance of Symmetrical and
Catalytic Performance of Symmetrical and Unsymmetrical Sulfur-Containing Pincer Complexes: Synthesis and Tandem Catalytic Activity of the First PCS-Pincer Palladium Complex
✍ Marcella Gagliardo; Nicklas Selander; Nilesh C. Mehendale; Gerard van Koten; Rob 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 508 KB

## Abstract The synthesis and catalytic applications of a new aryl‐based unsymmetrical PCS‐pincer complex are reported. Preparation of the robust air‐ and moisture‐stable PCS‐pincer palladium complex 5[X] started from the symmetrical α,α′‐dibromo‐__meta__‐xylene and involved the selective substitut