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Palladium(ii)-catalyzed synthesis of functionalized indenones via oxidation and cyclization of 2-(2-arylethynylphenyl)acetonitriles

โœ Scribed by Chen, Xuxing; He, Qian; Xie, Yuyuan; Yang, Chunhao


Book ID
120178319
Publisher
Royal Society of Chemistry
Year
2013
Tongue
English
Weight
199 KB
Volume
11
Category
Article
ISSN
1477-0520

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An efficient procedure for the synthesis of 2,2-disubstituted benzocyclic ketones by intramolecular carbopalladation of nitriles has been developed. The cyclization of substituted 3-(2-iodoaryl)propanenitriles affords indanones in high yields. The reaction is compatible with a wide variety of functi