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Palladium(II)-Catalyzed Enantio- and Diastereoselective Synthesis of Pyrrolidine Derivatives

โœ Scribed by Jana, Ranjan; Pathak, Tejas P.; Jensen, Katrina H.; Sigman, Matthew S.


Book ID
115451999
Publisher
American Chemical Society
Year
2012
Tongue
English
Weight
800 KB
Volume
14
Category
Article
ISSN
1523-7060

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The enantio- and diastereoselective synt
โœ Joseph F Dellaria Jr.; Robert G Maki ๐Ÿ“‚ Article ๐Ÿ“… 1986 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 191 KB

The title compound was synthesized by the diastereoselective addition of the lithium or sodium anion of dimethyl methylphosphonate to fi-trityl-L-phenylalaninal. Inhibition of renin, an aspartic proteinase, is a current area of intense research. 1 Incorporation of statine (1) (R = L -pr), and deriva