✦ LIBER ✦
Palladium(II)-catalyzed dicarboxymethylation of chiral allylic alcohols: chirality transfer affording optically active diesters containing three contiguous chiral centers
✍ Scribed by Othman Hamed; Patrick M. Henry; Daniel P. Becker
- Book ID
- 104097778
- Publisher
- Elsevier Science
- Year
- 2010
- Tongue
- French
- Weight
- 680 KB
- Volume
- 51
- Category
- Article
- ISSN
- 0040-4039
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✦ Synopsis
This manuscript describes the extension of Stille's palladium-catalyzed olefin dicarbonylation reaction to chiral allylic alcohols with chirality transfer to afford the corresponding chiral alcohol functionalized with bis-carbomethoxy esters, containing three contiguous chiral centers, in good to excellent diastereoselectivities (78-98%).