Palladium(II) and Platinum(II) Organometallic Complexes with the Model Nucleobase Anions of Thymine, Uracil, and Cytosine: Antitumor Activity and Interactions with DNA of the Platinum Compounds ○
✍ Scribed by Ruiz, José; Lorenzo, Julia; Sanglas, Laura; Cutillas, Natalia; Vicente, Consuelo; Villa, María Dolores; Avilés, Francesc X.; López, Gregorio; Moreno, Virtudes; Pérez, José; Bautista, Delia
- Book ID
- 126053692
- Publisher
- American Chemical Society
- Year
- 2006
- Tongue
- English
- Weight
- 615 KB
- Volume
- 45
- Category
- Article
- ISSN
- 0020-1669
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2.2.3 Reactions of Pro-Gly-Ala-His and His-Pro-Gly-Ala-His with [Pd(en)(D 2 O) 2 ] 2 + and cis-[Pt(NH 3 )(D 2 O) 2 ] 2 + .
The reaction of Pd(Me,en)Cl, (Me,en =N,N,iV',N'-tetramethylethylenediamine) with inosine and 5'-inosine monophosphate was studied as a function of chloride concentration and pH. Evidence for the formation of a 1:l complex with these nucleophiles is presented, and the kinetic data indicate that Pd(Me