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Palladium(II) and Platinum(II) Organometallic Complexes with the Model Nucleobase Anions of Thymine, Uracil, and Cytosine: Antitumor Activity and Interactions with DNA of the Platinum Compounds ○

✍ Scribed by Ruiz, José; Lorenzo, Julia; Sanglas, Laura; Cutillas, Natalia; Vicente, Consuelo; Villa, María Dolores; Avilés, Francesc X.; López, Gregorio; Moreno, Virtudes; Pérez, José; Bautista, Delia


Book ID
126053692
Publisher
American Chemical Society
Year
2006
Tongue
English
Weight
615 KB
Volume
45
Category
Article
ISSN
0020-1669

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Mechanistic information on the reaction
✍ M. Shoukry; H. Hohmann; R. van Eldik 📂 Article 📅 1992 🏛 Elsevier Science 🌐 English ⚖ 572 KB

The reaction of Pd(Me,en)Cl, (Me,en =N,N,iV',N'-tetramethylethylenediamine) with inosine and 5'-inosine monophosphate was studied as a function of chloride concentration and pH. Evidence for the formation of a 1:l complex with these nucleophiles is presented, and the kinetic data indicate that Pd(Me