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Palladium-mediated synthesis of novel nimesulide derivatives

✍ Scribed by Shylaprasad Durgadas; Vijay kumar Chatare; Khagga Mukkanti; Sarbani Pal

Publisher
John Wiley and Sons
Year
2010
Tongue
English
Weight
117 KB
Volume
24
Category
Article
ISSN
0268-2605

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✦ Synopsis

Abstract

Synthesis of a series of compounds structurally related to the anti‐inflammatory agent nimesulide has been accomplished via Pd‐catalyzed CC bond forming reactions. Thus 4‐iodo derivative, prepared from nimesulide, participated in Sonogashira (copper‐free), Heck and Suzuki coupling reactions to afford the corresponding alkynyl, alkenyl and aryl substituted products. Some of the compounds synthesized were tested for anti‐inflammatory activities in vivo. Copyright © 2010 John Wiley & Sons, Ltd.

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Synthesis of novel quinoline analogues of nimesulide: An unusual observation
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## Abstract Reduction of nimesulide followed by treating the __N__‐acyl derivative of resulting arylamine with Vilsmeier‐Haack reagent provided novel 2‐chloro‐3‐formylquinoline derivatives. The construction of quinoline ring using Vilsmeier‐Haack reagent afforded an unexpected compound, __N__‐(2‐ch