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Palladium-catalyzed synthesis of cis-2-[4-(9H-Purin-9-yl)-2-cyclopenten-1-yl]ethanol analogues

✍ Scribed by Lakshmi B. Akella; Robert Vince


Publisher
Elsevier Science
Year
1996
Tongue
French
Weight
307 KB
Volume
52
Category
Article
ISSN
0040-4020

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Synthesis of carbon-14 labelled cis-2-am
✍ M. B. Gopinathan; J. A. Kepler πŸ“‚ Article πŸ“… 1991 πŸ› John Wiley and Sons 🌐 French βš– 183 KB

The synthesis of the title compound (3) is described. Treatment of a solution of triethyl [14C]orthoformate in dry chloroform with cis-[4-(2,5-diamino-6-chloro-4-pyrimidinyl) -amino] -2cyclopentenyl]carbinol (1) afforded crude 2. Hydrolysis of crude 2 with 2 N sodium Eydroxide gave 3 in 34% overall