Palladium-Catalyzed Synthesis of 2-Fluoroalkyl-3-methylene-3H-indoles Through a Domino Carbopalladation/CH Activation Process

✍ Scribed by Zixian Chen; Jiangtao Zhu; Haibo Xie; Shan Li; Yongming Wu; Yuefa Gong

• Publisher: John Wiley and Sons
• Year: 2011
• Tongue: English
• Weight: 186 KB
• Volume: 353
• Category: Article
• ISSN: 1615-4150
• DOI: 10.1002/adsc.201000689

✦ Synopsis

Abstract

A novel palladium‐catalyzed synthesis of substituted 3‐methylene‐3__H__‐indoles from readily accessible alkynylimines has been developed. A wide variety of 2‐fluoroalkyl‐3‐methylene‐3__H__‐indoles were synthesized in moderate to good yields through this cascade carbopalladation/CH activation process. This reaction can also be expanded to non‐fluorinated substrates.