Palladium-Catalyzed Sonogashira Coupling Reaction Followed by Isomerization and Cyclization.
✍ Scribed by Chan Sik Cho
- Publisher
- John Wiley and Sons
- Year
- 2005
- Weight
- 19 KB
- Volume
- 36
- Category
- Article
- ISSN
- 0931-7597
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✦ Synopsis
Abstract
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A variety of 4-(1-alkenyl)-3-arylisoquinolines have been prepared by the Pd(II)-catalyzed cyclization of 2-(1alkynyl)benzaldimines, followed by alkenylation (Heck reaction) in good to excellent yields. The introduction of an ortho-methoxy group on the benzaldimine promotes the Pd-catalyzed cyclizati
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## Abstract magnified image A polyurea‐encapsulated palladium catalyst (__Pd EnCat__^TM^ __30__) was first applied to __Sonogashira__ cross‐coupling reactions in the absence of a copper salt co‐catalyst and under phosphine‐free conditions. This polymer‐anchored homogeneous palladium catalyst effic