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Palladium-Catalyzed Sequential Reactions via Allene Intermediates for the Rapid Synthesis of Fused Polycyclic Pyrrole Derivatives

✍ Scribed by Xian Huang; Shugao Zhu; Ruwei Shen

Publisher: John Wiley and Sons
Year: 2009
Tongue: English
Weight: 177 KB
Volume: 351
Category: Article
ISSN: 1615-4150
DOI: 10.1002/adsc.200900503

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✦ Synopsis

In this paper, we report a novel sequential reaction sequence consisting of a series of processes including Sonogashira coupling, propargyl-allenyl isomerization, [3 + 2] cycloaddition, denitrogenation, and highly selective biradical coupling reaction, providing an efficient synthesis of fused polycyclic pyrrole derivatives. The reaction features one C À C bond and two C À N bonds formed to construct the pyrrole unit, together with two rings efficiently assembled in one stroke.

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