Palladium-Catalyzed Sequential Alkylation−Alkenylation Reactions. Application to the Synthesis of 2-Substituted-4-Benzoxepines and 2,5-Disubstituted-4-Benzoxepines
✍ Scribed by Lautens, Mark; Paquin, Jean-François; Piguel, Sandrine
- Book ID
- 120245910
- Publisher
- American Chemical Society
- Year
- 2002
- Tongue
- English
- Weight
- 43 KB
- Volume
- 67
- Category
- Article
- ISSN
- 0022-3263
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📜 SIMILAR VOLUMES
Easily available 3,4-dibromo-2(5H)-furanone undergoes a regioselective cross-coupling reaction with alkylboronic acids in the presence of catalytic amounts of PdCl2(MeCN)2 and AsPh3 and a large molar excess of Ag2O to provide the corresponding 4-alkyl-3-bromo-2(5H)-furanones in satisfactory yields.
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