Palladium-catalyzed hydroxycarbonylation as the key step in the synthesis of a carbon-14 labeled Maxi-K channel blocker

✍ Scribed by Joseph P. Simeone; Matthew P. Braun; Luping Liu; Swaminathan R. Natarajan

• Publisher: John Wiley and Sons
• Year: 2010
• Tongue: French
• Weight: 148 KB
• Volume: 53
• Category: Article
• ISSN: 0022-2135
• DOI: 10.1002/jlcr.1755

✦ Synopsis

Abstract

Carbon‐14 labeled sodium formate was utilized for the preparation of a radiolabeled tracer to support the development of a Maxi‐K channel blocker. Key to the process was a palladium‐catalyzed hydroxycarbonylation of a bromoarene for installation of the radiolabel. Copyright © 2010 John Wiley & Sons, Ltd.