Palladium-Catalyzed Heck Arylations in the Synthesis of Active Pharmaceutical Ingredients
β Scribed by Prashad, Mahavir
- Book ID
- 120968019
- Publisher
- Springer Berlin Heidelberg
- Tongue
- English
- Weight
- 470 KB
- Category
- Article
- ISSN
- 0167-5273
- DOI
- 10.1007/b11771
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π SIMILAR VOLUMES
## Abstract The use of palladiumβderived catalysts in the synthesis of fine chemicals, pharmaceutical intermediates and active pharmaceutical ingredients (APIs) has become quite common in the last few decades. The number of palladiumβcatalyzed synthetic reactions (both achiral and chiral) available
N-Alkyl O-cinnamyl carbamates (3) were prepared in good yields by palladium cat-'alyzed arylation of N-alkyl O-ally1 carbamak s (2) with aryl iodides. Heck type arylation of allylic alcohols with aromatic1 and IWemammatic halides2 is an efficient entry to the preparation of aromatic-substituted alky