✦ LIBER ✦
Palladium-Catalyzed Decarboxylative sp-sp2 Cross-Coupling Reactions of Aryl and Vinyl Halides and Triflates with α,β-Ynoic Acids using Silver Oxide
✍ Scribed by Hyunseok Kim; Phil Ho Lee
- Publisher
- John Wiley and Sons
- Year
- 2009
- Tongue
- English
- Weight
- 209 KB
- Volume
- 351
- Category
- Article
- ISSN
- 1615-4150
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✦ Synopsis
Abstract
Palladium‐catalyzed decarboxylative sp‐sp^2^ cross‐coupling reactions of aryl and vinyl halides and triflates with α,β‐ynoic acids using silver oxide have been developed. A variety of α,β‐ynoic acids were readily decarboxylated in the presence of silver oxide and then, generated in situ, silver acetylides were coupled with electrophiles in the presence of a palladium(0) catalyst under neutral conditions, producing either symmetrical or unsymmetrical diarylacetylenes, arylalkylacetylenes and arylvinylacetylenes in good to excellent yields.