Palladium-catalyzed cyclization of 3-bromopyridine-4-carbaldehyde with carbon monoxide and carboxylic acids

✍ Scribed by Chan Sik Cho; Jun Uk Kim

• Publisher: Journal of Heterocyclic Chemistry
• Year: 2008
• Tongue: English
• Weight: 249 KB
• Volume: 45
• Category: Article
• ISSN: 0022-152X
• DOI: 10.1002/jhet.5570450523

✦ Synopsis

Abstract

magnified image

3‐Bromopyridine‐4‐carbaldehyde is cyclized with carboxylic acids in acetonitrile at 100° under carbon monoxide pressure in the presence of a catalytic amount of a palladium catalyst along with a base to afford the corresponding 3‐oxo‐1,3‐dihydrofuro[3,4‐c]pyridine‐1‐yl alkanoates in moderate to good yields.