Palladium-catalyzed cross-coupling reaction of alkenylalkoxysilanes with aryl and alkenyl halides in the presence of a fluoride ion

✍ Scribed by Kohei Tamao; Kenji Kobayashi; Yoshihiko Ito

• Publisher: Elsevier Science
• Year: 1989
• Tongue: French
• Weight: 254 KB
• Volume: 30
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(01)93852-3

✦ Synopsis

Alkenyl-monoalkoxydimethylsilanes, dialkoxymethylsilanes,

and trialkoxysilanes undergo palladium-catalyzed cross-coupling reaction with alkenyl and aryl halides in the presence of tetra-n-butylammonium fluoride. A one-pot transformation of a homopropargyl alcohol to regio-and stereo-defined trisubstituted homoallyl alcohols has been achieved by a sequence of intramolecular hydrosilation and the palladium-catalyzed coupling reaction.