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Palladium-catalyzed cross-coupling reaction of 2- and/or 5-substituted 4,6-dichloropyrimidines with arylboronic acids

✍ Scribed by S. Tumkevicius; J. Dodonova; I. Baskirova; A. Voitechovicius

Publisher
Journal of Heterocyclic Chemistry
Year
2009
Tongue
English
Weight
85 KB
Volume
46
Category
Article
ISSN
0022-152X

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✦ Synopsis

Abstract

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The Suzuki‐Miyaura reaction of some 4,6‐dichloropyrimidines bearing methylthio‐, methyl‐, amino‐, cyano‐, formyl‐, and nitro groups in positions 2 and/or 5 of the pyrimidine ring with arylboronic acids has been investigated. Influence of palladium catalyst, ligand, base, and solvent on the reaction outcome was studied. The reaction was found to give the corresponding 4,6‐diarylpyrimidines in reasonable yields using Pd(OAc)~2~/PPh~3~/K~3~PO~4~ or Pd(PPh~3~)~2~Cl~2~/K~3~PO~4~ as catalyst systems. J. Heterocyclic Chem., (2009).

📜 SIMILAR VOLUMES

ChemInform Abstract: Palladium-Catalyzed
ChemInform Abstract: Palladium-Catalyzed Cross-Coupling Reaction of 2- and/or 5-Substituted 4,6-Dichloropyrimidines with Arylboronic Acids.
✍ S. Tumkevicius; J. Dodonova; I. Baskirova; A. Voitechovicius 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 43 KB 👁 1 views

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