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Palladium-Catalyzed C2 or C5 Direct Arylation of 3-Formylthiophene Derivatives with Aryl Bromides

✍ Scribed by Jia Jia Dong; Henri Doucet


Publisher
John Wiley and Sons
Year
2010
Tongue
English
Weight
399 KB
Volume
2010
Category
Article
ISSN
1434-193X

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Regioselective C-2 or C-5 Direct Arylati
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## Abstract A simple and atom‐economical procedure for the regioselective C‐2 or C‐5 arylation of pyrroles __via__ a Cο£ΏH bond activation is reported. Only 0.5–0.01 mol% of commercially available and air‐stable ligand‐free palladium(II) acetate [Pd(OAc)~2~] was employed as the catalyst. The presence