Palladium-catalyzed asymmetric alkoxycarbonylation of allyl phosphates

✍ Scribed by Yasushi Imada; Masaru Fujii; Yasushi Kubota; Shun-Ichi Murahashi

• Book ID: 104258274
• Publisher: Elsevier Science
• Year: 1997
• Tongue: French
• Weight: 222 KB
• Volume: 38
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(97)10201-5

✦ Synopsis

Palladium-catalyzed alkoxycarbonylation of allyl phosphates proceeds with high efficiency affording the corresponding [3,y-unsaturatod esters stereoselectively with inversion of configuration at the allylic carbon center. Palladium complexes bearing chiral monodentate phosphine ligands are effective catalysts for asymmetric allylic carbonylation of cyclohex-2-en-l-yl phosphates 1 to give optically active cyclohex-2-ene-1--carboxylates 2 in moderate enantiomeric excesses.