## Abstract Lawsone (I) is used as starting material for the optimized reductive alkylation process to yield the title compounds including phthiocol (IIa) and lapachol (IIIb).
Palladium-Catalyzed Allylation of 2-Hydroxy-1,4-naphthoquinone: Application to the Preparation of Lapachol.
β Scribed by Georgia Kazantzi; Elizabeth Malamidou-Xenikaki; Spyros Spyroudis
- Publisher
- John Wiley and Sons
- Year
- 2007
- Weight
- 31 KB
- Volume
- 38
- Category
- Article
- ISSN
- 0931-7597
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π SIMILAR VOLUMES
The mechanisms of toxicity to isolated rat hepatocytes of two structurally related naphthoquinones have been studied. Both 5-OH-1,4-naphthoquinone (5-OH-1,4-NQ; juglone) and 2-OH-1,4-naphthoquinone (2-OH-1,4-NQ; lawsone) caused a concentration-dependent cytotoxicity to hepatocytes which was preceded
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