## Abstract The first palladium‐ and copper‐mediated C‐2 arylations of thiazole, oxazole, __N__‐methylimidazole and __N__‐arylimidazoles, as well as of free (NH)‐imidazole, ‐benzimidazole and ‐indole, with aryl iodides under ligandless and base‐free conditions are described. Complete selectivity ha
Palladium- and Copper-Mediated Direct C-2 Arylation of Azoles — Including Free (NH)-Imidazole, - Benzimidazole and -Indole — Under Base-Free and Ligandless Conditions.
✍ Scribed by Fabio Bellina; Silvia Cauteruccio; Renzo Rossi
- Publisher
- John Wiley and Sons
- Year
- 2006
- Weight
- 18 KB
- Volume
- 37
- Category
- Article
- ISSN
- 0931-7597
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✦ Synopsis
Abstract
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## Abstract A large variety of 1,2‐diaryl‐1__H__‐imidazoles, including a selective COX‐2 inhibitor, have been regioselectively synthesised in moderate to high yields by direct coupling of 1‐aryl‐1__H__‐imidazoles with aryl iodides or bromides in DMF in the presence of CsF and catalytic amounts of P