Palatal myoclonus: Treatment with 5-hydroxytryptophan and carbidopa
β Scribed by Mohit Bhatt; Barry Snow; Michael Varelas; Donald Calne
- Publisher
- John Wiley and Sons
- Year
- 1990
- Tongue
- English
- Weight
- 190 KB
- Volume
- 5
- Category
- Article
- ISSN
- 0885-3185
No coin nor oath required. For personal study only.
β¦ Synopsis
that an individual is less efficient at detoxifying MPTP and like compounds during first-pass metabolism, could leave a person at risk of toxicity. Slowly accumulating nigral damage would explain the tendency for the disease to increase in incidence with age, and differences in environmental dosage would explain the low concordance of clinically evident disease in monozygotic twins.
π SIMILAR VOLUMES
The electrochemically driven oxidation of 5-hydroxytryptophan (5-HTPP) in the presence of free glutathione (GSH) yields 4-S-glutathionyl-5-hydroxytryptophan (5) and 7-S-glutathionyltryptophan-4,5-dione (7). The latter glutathionyl conjugate is formed both by nucleophilic addition of GSH to tryptopha