Paget's disease and osteoclast biology
β Scribed by Roodman, G.D.
- Book ID
- 123090585
- Publisher
- Elsevier Science
- Year
- 1996
- Tongue
- English
- Weight
- 459 KB
- Volume
- 19
- Category
- Article
- ISSN
- 8756-3282
No coin nor oath required. For personal study only.
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## Abstract Paget's disease of bone is a chronic focal skeletal disorder that affects up to 2β3% of the population over the age of 60 years. Paget's disease is primarily a disease of the osteoclast. The pathologic abnormality in patients with Paget's disease involves increased bone resorption by th
## Abstract Paget's disease is characterized by markedly increased osteoclast formation and bone resorption followed by excessive new bone formation. Osteoclasts in Paget's disease are increased both in number and size, contain paramyxoviralβlike nuclear inclusions, and can have up to 100 nuclei pe