Two important mediators of endothelium-dependent regulation of vascular smooth muscle tone and proliferation are nitric oxide (NO) and endothelin (ET-1). An imbalance between NO and ET-1 may contribute to the alterations in vascular tone characteristic of cardiovascular disease. The objective of thi
β¦ LIBER β¦
PAF ANTAGONISTS BLOCK INDUCTION OF NITRIC OXIDE SYNTHASE IN CULTURED MACROPHAGES AND VASCULAR SMOOTH MUSCLE CELLS
β Scribed by Jane F. Arthur; Susan Shahin; Gregory J. Dusting
- Book ID
- 108936617
- Publisher
- John Wiley and Sons
- Year
- 1995
- Tongue
- English
- Weight
- 302 KB
- Volume
- 22
- Category
- Article
- ISSN
- 0305-1870
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## Abstract Proliferative modification of vascular smooth muscle cell (vSMC) and impaired bioavailability of nitric oxide (NO) have both been proposed among the mechanisms linking diabetes and atherosclerosis. However, diabetes induced modifications in phenotype and nitric oxide synthase(s) (NOS) e