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PAD4 is not essential for disease in the K/BxN murine autoantibody-mediated model of arthritis

✍ Scribed by Amanda S Rohrbach, Saskia Hemmers, Sanja Arandjelovic…

Book ID
120706118
Publisher
BioMed Central
Year
2012
Tongue
English
Weight
571 KB
Volume
14
Category
Article
ISSN
1478-6354

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## Abstract ## Objective Osteopontin (OPN) is a secreted glycoprotein involved in a range of physiologic processes, including inflammation, immunity mediated by Th1 cells, and bone remodeling. It is expressed in the joints of rheumatoid arthritis patients and has been the subject of conflicting re