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Paclitaxel stimulates chromosomal fusion and instability in cells with dysfunctional telomeres: Implication in multinucleation and chemosensitization

โœ Scribed by Jeong-Eun Park; Seon Rang Woo; Chang-Mo Kang; Kyoung-Mi Juhn; Yeun-Jin Ju; Hyun-Jin Shin; Hyun-Yoo Joo; Eun Ran Park; In-chul Park; Sung Hee Hong; Sang-Gu Hwang; Jung-Kee Lee; Hae Kwon Kim; Myung-Haing Cho; Gil Hong Park; Kee-Ho Lee


Book ID
116301191
Publisher
Elsevier Science
Year
2011
Tongue
English
Weight
527 KB
Volume
404
Category
Article
ISSN
0006-291X

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We describe the cytogenetic evolution of multiple cell lines in the gonadal tissue of a 10-year-old girl with mosaic Ullrich-Turner syndrome (UTS) involving clonal telomeric associations (tas) of the Y chromosome. Gband analysis of all tissues showed at least 2 cell lines; 45, X and 46,X,tas(Y;21)(q