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Paclitaxel metabolism in rat and human liver microsomes is inhibited by phenolic antioxidants

✍ Scribed by Radka Václavíková; Stanislav Horský; Petr Šimek; Ivan Gut

Publisher
Springer-Verlag
Year
2003
Tongue
English
Weight
517 KB
Volume
368
Category
Article
ISSN
0028-1298

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## Abstract Previous studies have established that chlorpyrifos (CPS), fipronil, and nonane can all be metabolized by human liver microsomes (HLM) and a number of cytochrome P450 (CYP) isoforms. However, metabolic interactions between these three substrates have not been described. In this study th