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PACAP Stimulates Biosynthesis and Release of Endozepines from Rat Astrocytes

✍ Scribed by OLFA MASMOUDI-KOUKI; PIERRICK GANDOLFO; JEROME LEPRINCE; DAVID VAUDRY; GEORGES PELLETIER; ALAIN FOURNIER; HUBERT VAUDRY; MARIE-CHRISTINE TONON

Book ID
111478712
Publisher
John Wiley and Sons
Year
2006
Tongue
English
Weight
90 KB
Volume
1070
Category
Article
ISSN
0890-6564

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Astroglial cells synthesize and release endozepines, a family of neuropeptides derived from diazepam-binding inhibitor (DBI). The authors have recently shown that b-amyloid peptide (Ab) stimulates DBI gene expression and endozepine release. The purpose of this study was to determine the mechanism of