PACAP 1-38 as an Inhaled Bronchodilator in Guinea Pigs In Vivo
✍ Scribed by Anders Lindén; Lars-Olaf Cardell; Shigemi Yoshihara; Pär Stjärne; Jay A Nadel
- Book ID
- 117409080
- Publisher
- Elsevier Science
- Year
- 1998
- Tongue
- English
- Weight
- 141 KB
- Volume
- 19
- Category
- Article
- ISSN
- 0196-9781
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The potential of the potassium channel activator cromakalim and its active enantiomer BRL 38227 as inhaled bronchodilators has been evaluated in the guinea-pig, in comparison with nifedipine, salbutamol and aminophylline. Inhaled cromakalim and BRL 38227 prolonged the time before histamine-induced c
The novel potassium channel activator BRL 55834 and the prototype compound levcromakalim have been compared as inhaled bronchodilators in guinea-pigs and rats. Salbutamol was included in the guinea-pig studies. In anaesthetized guinea-pigs, inhaled BRL 55834 [ED50 = 0.9 (0.5-1.5) micrograms per anim