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PA26, a novel target of the p53 tumor suppressor and member of the GADD family of DNA damage and growth arrest inducible genes

✍ Scribed by Velasco-Miguel, Susana; Buckbinder, Leonard; Jean, Patrice; Gelbert, Larry; Talbott, Randy; Laidlaw, Jana; Seizinger, Bernd; Kley, Nikolai


Book ID
110061735
Publisher
Nature Publishing Group
Year
1999
Tongue
English
Weight
597 KB
Volume
18
Category
Article
ISSN
0950-9232

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## Abstract The p53 tumor suppressor gene, which is frequently mutated in a wide variety of tumors, plays an important role in maintaining genomic integrity. Following genotoxic insults, the protein level of p53 is increased, and p53 functions as a sequence‐specific transcription factor that regula