Hereditary spastic paraplegia (HSP) is a heterogeneous condition characterised in its pure form by progressive lower limb spasticity. Mutations in SPG4 (encoding spastin) may be responsible for up to 40% of autosomal dominant (AD) cases. A cohort of 41 mostly pure HSP patients from Britain and Austr
✦ LIBER ✦
P878: Incidence of functional alterations of somatosensory pathways in the hereditary spastic paraplegia SPG4
✍ Scribed by Rakowicz, M.; Stępniak, I.; Elert, E.; Sobańska, A.; Łojkowska, W.; Sułek, A.; Poniatowska, R.; Antczak, J.; Makowicz, G.; Zalewska, U.; Więcławska, M.
- Book ID
- 125796854
- Publisher
- Elsevier Science
- Year
- 2014
- Tongue
- English
- Weight
- 232 KB
- Volume
- 125
- Category
- Article
- ISSN
- 1388-2457
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Hereditary spastic paraplegias (HSP) comprise a genetically and clinically heterogeneous group of neurodegenerative disorders characterized by progressive spasticity and hyperreflexia of the lower limbs. Autosomal dominant hereditary spastic paraplegia 4 linked to chromosome 2p (SPG4) is the most co
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