P.8.002 Hydrolysis of 1-methyl-5-phenyl-3-acetoxy-7-bromo-1,2-dihydro-3H-1,4-benzodiazepine-2-one with the help of pig liver microsomes
β Scribed by E.A. Shesterenko; I.I. Romanovska; O.V. Sevastyanov; S.A. Andronati; V.I. Pavlovsky; T.I. Yurpalova; E.A. Semenishina
- Book ID
- 118597934
- Publisher
- Elsevier Science
- Year
- 2011
- Tongue
- English
- Weight
- 57 KB
- Volume
- 21
- Category
- Article
- ISSN
- 0924-977X
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π SIMILAR VOLUMES
The selective basic hydrolysis of 3-acetoxy-?-bromoJ-(o-chlorophenyl)-l-ethoxycarbonylmethyl-l,2dihydro-3H-1,4-bep,~,epin-2-one has been carried out, resulting in the sequential formation of 3-hydroxy-]-ethoxycarbonylmethyl-, 3-hydroxy-l-methoxycarbonylmethyl-, and 3-hydroxy-l-carboxymethyl derivati
## Abstract Two benzodiazepines, Diazepam and Flunitrazepam, labeled with carbonβ14 in position 5 of the diazepine ring have been synthesized. Use of a condensation between iminochlorides and ^14^Cβbenzonitriles, followed by exhaustive methylation of the resulting quinazolines and hydrolyses is des