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P.8.002 Hydrolysis of 1-methyl-5-phenyl-3-acetoxy-7-bromo-1,2-dihydro-3H-1,4-benzodiazepine-2-one with the help of pig liver microsomes

✍ Scribed by E.A. Shesterenko; I.I. Romanovska; O.V. Sevastyanov; S.A. Andronati; V.I. Pavlovsky; T.I. Yurpalova; E.A. Semenishina


Book ID
118597934
Publisher
Elsevier Science
Year
2011
Tongue
English
Weight
57 KB
Volume
21
Category
Article
ISSN
0924-977X

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The selective basic hydrolysis of 3-acetoxy-?-bromoJ-(o-chlorophenyl)-l-ethoxycarbonylmethyl-l,2dihydro-3H-1,4-bep,~,epin-2-one has been carried out, resulting in the sequential formation of 3-hydroxy-]-ethoxycarbonylmethyl-, 3-hydroxy-l-methoxycarbonylmethyl-, and 3-hydroxy-l-carboxymethyl derivati

The synthesis of 7-chloro-1-methyl-5-phe
✍ H. H. Kaegi; W. Burger; C. J. Bader πŸ“‚ Article πŸ“… 1982 πŸ› John Wiley and Sons 🌐 French βš– 393 KB πŸ‘ 1 views

## Abstract Two benzodiazepines, Diazepam and Flunitrazepam, labeled with carbon‐14 in position 5 of the diazepine ring have been synthesized. Use of a condensation between iminochlorides and ^14^C‐benzonitriles, followed by exhaustive methylation of the resulting quinazolines and hydrolyses is des