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p75NTR and the concept of cellular dependence: seeing how the other half die

✍ Scribed by Bredesen, Dale E; Ye, Xin; Tasinato, Andrea; Sperandio, Sabina; Wang, James JL; Assa-Munt, Nuria; Rabizadeh, Shahrooz


Book ID
110015785
Publisher
Nature Publishing Group
Year
1998
Tongue
English
Weight
241 KB
Volume
5
Category
Article
ISSN
1350-9047

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## Abstract The retinoblastoma tumor suppressor gene (__RB1__) is currently the only known gene whose mutation is necessary and sufficient for the development of a human cancer. Mutation or deregulation of RB1 is observed so frequently in other tumor types that compromising RB1 function may be a pr