p73 modulates HIV-1 Tat transcriptional and apoptotic activities in human astrocytes
โ Scribed by M. Saunders; M. B. Eldeen; L. Del Valle; K. Reiss; F. Peruzzi; G. Mameli; B. B. Gelman; K. Khalili; S. Amini; B. E. Sawaya
- Book ID
- 106349268
- Publisher
- Springer
- Year
- 2005
- Tongue
- English
- Weight
- 943 KB
- Volume
- 10
- Category
- Article
- ISSN
- 1360-8185
No coin nor oath required. For personal study only.
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## Abstract Transcription of the HIVโ1 genome is a complex event that requires functional and physical communication of cellular proteins that recognize the LTR sequence with viral proteins, most notably, Tat. Moreover, studies have revealed the ability of Tat to induce transcription of a variety o
## Abstract Infection with HIVโ1 causes degeneration of neurons leading to motor and cognitive dysfunction in AIDS patients. One of the key viral regulatory proteins, Tat, which is released by infected cells, can be taken up by various uninfected cells including neurons and by dysregulating several