P6. The control of osteoclastic function by prostaglandins
β Scribed by Fuller, K; Chambers, TJ
- Book ID
- 123265168
- Publisher
- Elsevier Science
- Year
- 1988
- Tongue
- English
- Weight
- 136 KB
- Volume
- 9
- Category
- Article
- ISSN
- 8756-3282
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## Abstract Fibroblast growth factorβ6 (FGFβ6) is known to be the key ligand for fibroblast growth factor receptor 4 (FGFR4) during muscle regeneration but its role in bone has yet to be verified. FGFR signaling is known to be important in the initiation and regulation of osteogenesis, so in this s
We have recently found that calcitonin (CT), a hormone which inhibits osteoclastic bone resorption, completely abolishes the normally intense cytoplasmic motility of isolated osteoclasts. Here we report that prostaglandin (PG)I2, PGE1, PGE2 and 6-oxo-PGE1 cause an identical change in behaviour to th