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p53 Variants Predisposing to Cancer Are Present in Healthy Centenarians

✍ Scribed by Massimiliano Bonafè; Fabiola Olivieri; Daniela Mari; Giovannella Baggio; Rosario Mattace; Paolo Sansoni; Giovanna De Benedictis; Maria De Luca; Stefano Bertolini; Cristiana Barbi; Daniela Monti; Claudio Franceschi


Book ID
117852673
Publisher
American Society of Human Genetics
Year
1999
Tongue
English
Weight
52 KB
Volume
64
Category
Article
ISSN
0002-9297

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p53 Mutations are present in colorectal
✍ Agneta Jansson; Massimiliano Gentile; Xiao-Feng Sun 📂 Article 📅 2001 🏛 John Wiley and Sons 🌐 French ⚖ 401 KB

Previous studies have shown that nuclear p53 over-expression is an indicator of p53 mutations whereas cytoplasmic p53 accumulation is related to wild-type p53 in several kinds of tumors. Cytoplasmic p53 accumulation has been demonstrated to be an independent prognostic factor in colorectal adenocarc