p53 point mutation enhanced by hepatic regeneration in aflatoxin B1-induced rat liver tumors and preneoplastic lesions

Absence of p53 mutations and various fre

Absence of p53 mutations and various frequencies of ki-ras exon 1 mutations in rat hepatic tumors induced by different carcinogens

✍ Yoshihiko Tokusashi; Ikue Fukuda; Katsuhiro Ogawa 📂 Article 📅 1994 🏛 John Wiley and Sons 🌐 English ⚖ 638 KB

## Abstract Mutations of __p53__ and Ki‐__ras__ exon 1 were investigated in rat hepatic lesions induced by four kinds of hepatocarcinogenic protocols: continuous feeding of 3′‐methyl‐4‐dimethylaminoazobenzene (3′‐Me‐DAB), daily intraperitoneal injection of aflatoxin B, (AFB,), and the Soft and Farb