p53 mutations isolated in yeast based on loss of transcription factor activity: similarities and differences from p53 mutations detected in human tumors

Evidence that mutational activation of t

Evidence that mutational activation of the ras genes may not be involved in aflatoxin B1–induced human hepatocarcinogenesis, based on sequence analysis of the ras and p53 genes

✍ Hung-Kun Chao; Ting-Fen Tsai; Chang-Shen Lin; Tsung-Sheng Su 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 143 KB 👁 2 views

Exposure to aflatoxin B 1 (AFB 1 ) is one of the risk factors for developing hepatoma. In rats, activation of the ras gene is a prevalent event in AFB 1 -induced hepatocarcinogenesis. It is not clear whether a similar event occurs in humans. By analysis of codon 249 of the p53 gene, six of 36 human