Mutations in the p53 tumour-suppressor gene (exons 5-8) were investigated in 31 Belarussian childhood thyroid tumours (24 cases of papillary thyroid carcinoma, 3 benign tumours and 2 cases each of thyroiditis and goiter); 33 thyroid tumours from juveniles and adults without radiation exposures (25 c
P53 mutations in thyroid tumors of the dog
β Scribed by I.S. van Leeuwen; A. Voesten; P. Devilee; G.R. Rutteman
- Book ID
- 119106290
- Publisher
- Elsevier Science
- Year
- 1994
- Tongue
- English
- Weight
- 92 KB
- Volume
- 77
- Category
- Article
- ISSN
- 0165-4608
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Non-familial human adrenocortical adenomas and carcinomas were screened for mutations in exons 5-8 of the p53 tumor suppressor gene by single-strand-conformation-polymorphism (SSCP) analysis, followed by direct sequencing of PCR-amplified DNA. Point mutations in codons 12, 13 and 61 in H-ras, K-ras
## Abstract We investigated the frequency of p53 mutations in 47 pediatric brain tumors of various histologic subtypes that were collected over a period of 5 years. The specimens included 15 primitive neuroectodermal tumors (PNETs), 17 low grade astrocytomas, one anaplastic astrocytoma, three gliob