p53 mutations in BRCA1-associated familial breast cancer
β Scribed by Tim Crook; Susan Crossland; Mark R Crompton; Pinchas Osin; Barry A Gusterson
- Book ID
- 118550604
- Publisher
- The Lancet
- Year
- 1997
- Tongue
- English
- Weight
- 57 KB
- Volume
- 350
- Category
- Article
- ISSN
- 0140-6736
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We have screened index cases from 25 Russian breast/ovarian cancer families for germ-line mutations in all coding exons of the BRCA1 and BRCA2 genes, using multiplex heteroduplex analysis. In addition we tested 22 patients with breast cancer diagnosed before age 40 without family history and 6 patie
Germline mutation analysis of BRCA1 gene has demonstrated significant allelic heterogeneity. These differences represent historical influences of migration, population structure and geographic or cultural isolation. To date, there have been no reports of Indian families with mutations in BRCA1. We h