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p53 mutations and microsatellite instabilities in the subtype of intestinal metaplasia of the stomach and its role as a precancerous lesion

✍ Scribed by Kim, Sung Soo; Bhang, Choon Sang; Lee, Hak Sung; Chae, Hiun Suk; Chung, In Sik; Park, Doo Ho

Book ID: 124138899
Publisher: Elsevier Science
Year: 2001
Tongue: English
Weight: 372 KB
Volume: 120
Category: Article
ISSN: 0016-5085
DOI: 10.1016/S0016-5085(08)81486-2

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In order to ascertain whether genetic alterations occur during the early stages of gastric carcinogenesis. abnormal accumulation of p53 protein and mutation of its gene in stomach tissue showing intestinal metaplasia were investigated using immunohistochemistry and polymerase chain reaction-single s